Since Yanagisawa et al 1998 described the first Endothelin as a potent vasoconstrictor peptide, many other Endothelins and Endothelin related peptides have been isolated and reported. All the members of the Endothelin family show two disulfide bonds between the cysteine resisidues 1 - 15 and 3 - 11. The overexpression of endothelin peptides, especionally of Endothelin-1 plays an important role in generation of heart diseases. PeptaNova offers 12 different Endothelin peptides manufactured from Peptide Institute, Inc. Osaka. All offered Endothelin peptides are of synthetic origin, highly purified and tested of biological activity with dedicated essays.
Sarafatoxin (B and C) isolated from the snake venom of Atractaspis engaddensis shows many similarities to the Endothelin peptides and can be ordered from PeptaNova as well.
4198-s 0.1 mg | 4198-v 0.5 mg Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp
4360-s 0.1 mg Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - Val - Asn - Thr - Pro - Glu - His - Val - Val - Pro - Tyr
4208-s 0.1 mg | 4208-v 0.5 mg Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - Val - Asn - Thr - Pro - Glu - His - Val - Val - Pro - Tyr - Gly - Leu - Gly - Ser - Pro - Arg - Ser
4207-s 0.1 mg | 4207-v 0.5 mg Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - Val - Asn - Thr - Pro - Glu - His - Ile - Val - Pro - Tyr - Gly - Leu - Gly - Ser - Pro - Ser - Arg - Ser
4266-s 0.1 mg Cys - Ser - Cys - Ser - Ser - Leu - Met - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - Val - Asn - Thr - Pro - Glu - Arg - Val - Val - Pro - Tyr - Gly - Leu - Gly - Ser - Pro - Ser - Arg - Ser
4222-s 0.1 mg Cys - Ser - Cys - Ser - Ser - Trp - Leu - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - Val - Asn - Thr - Pro - Glu - Gln - Thr - Ala - Pro - Tyr - Gly - Leu - Gly - Asn - Pro - Pro
4253-s 0.1 mg Cys - Ser - Cys - Ser - Ser - Trp - Leu - Asp - Lys - Glu - Cys - Val - Tyr - Phe - Cys - His - Leu - Asp - Ile - Ile - Trp - Val - Asn - Thr - Pro - Glu - Gln - Thr - Ala - Pro - Tyr - Gly - Leu - Gly - Asn - Pro - Pro - Arg