Seven members of the Neuromedin family are available from PeptaNova. Neuromedin B , a decapeptide was originally isolated from porcine spinal cord. This bombesin -like peptide seems to play a role in the inhibition of of thyrotropin release and regulation in the central nervous system. Neuromedin C , a decapeptide as well, shows effects on exocrine pancreatic function and insulin release. Neuromedin K (Neurokinin B), a member of the tachykinin family was found to be the most potent agonist (EC50 = 1 nM) for the neuronal NK3 receptor. Neuromedin L (Neurokinin A), a tachykinin peptide is a NK2 receptor selective agonist. Neuromedin S was isolated from rat brain extracts. The research using this multifunctional novel peptide will be interesting in relation to that performed by the structurally related peptide Neuromedin U. Neuromedin U , possessing uterus contractile activity, was first isolated from porcine spinal cord as NMU-8 and NMU-25. Neuromedin U may be one of the physiological mediators of food intake and may be useful in clarifying the intricate mechanism of obesity and leanness
4427-s 0.1 mg Leu - Pro - Arg - Leu - Leu - His - Thr - Asp - Ser - Arg - Met - Ala - Thr - Ile - Asp - Phe - Pro - Lys - Lys - Asp - Pro - Thr - Thr - Ser - Leu - Gly - Arg - Pro - Phe - Phe - Leu - Phe - Arg - Pro - Arg - Asn - NH2
