The peptides of the Sarafotoxin family have been originally isolated from the venom of Atractaspis engaddensis, a snake located in Palestine. The structure, sequence and biological activity of these Sarafotoxin peptides are very similar to the members of the Endothelin-Family. It seems that these new vasoconstrictor peptide toxins binds selectively to atrial and brain membranes and have direct influence on the phosphoinositide phosphodiesterase system. PeptaNova offers two chemically synthesized Sarafotoxin peptides - Sarafotoxin S6b and S6c of highest quality. The biological activity of our Sarafotoxin peptides is examined by the pharmacological division, Peptide Institute, Inc.
