AAF-CMK

55,00 € excl. 19% VAT

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SKU: 3202-v Category:

AAF-CMK
Ala-Ala-Phe-CH2Cl | Ala-Ala-Phe-chloromethylketone

3202-v 5 mg | 55.00 EUR

L-Alanyl- L-alanyl- L-phenylalanyl- chloromethane (Trifluoroacetate Form)

(M.W. 339.82) C16H22N3O3Cl [102129-66-8]

Synthetic Product

Irreversible Inhibitor for Tripeptidyl Peptidase II (Component of Giant Protease with Some Proteasome Function), Chymotrypsin and Chymase

The synthetic serine protease inhibitor AAF-CMK, code 3202-v inhibits tripeptidyl peptidase II (TPP II) irreversibly and inhibits TPP I reversibly. Interference of this Tripeptidyl peptidase II (TPPII) with the chymotrypsin-like activity of the proteasome seems to be negligible. Inhibition of bleomycin hydrolase by inhibitor AAF-CMK is reported.

References:

  1. R. Glas, M. Bogyo, J.S. McMaster, M. Gaczynska and H.L. Ploegh, Nature, 392, 618 (1998)
  2. E. Geier, G. Pfeifer, M. Wilm, M. Lucchiari-Hartz, W. Baumeister, K. Eichmann and G. Niedermann, Science, 283, 978 (1999)
  3. D. Leung, G. Abbenante and D.P. Fairlie, J. Med. Chem. 43, 305 (2000)
  4. C. Rose et al, Neuropeptides 28, 157 (1995)

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