Ac-Asp-Glu-Val-Asp-AMC

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Ac-Asp-Glu-Val-Asp-AMC | Ac-DEVD-AMC

Ac-Asp-Glu-Val-Asp-MCA | Ac-DEVD-MCA

3171-v 5 mg | 72.00 EUR

Acetyl- L-aspartyl- L-glutamyl- L-valyl- L-aspartic acid α-(4-methyl- coumaryl- 7- amide)

(M.W. 675.65) C30H37N5O13 [169322-61-0]

Synthetic Product
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Selective Substrate for Caspase-3/7/8 (apopain; Yama; CPP-32)

Ac-DEVD-AMC is a selective fluoreogenic caspase substrate taken out of the sequence of the target enzyme Poly (ADP-ribose) polymerase. The fluorogenic tetrapeptide substrate Ac-DEVD-AMC is a useful tool for the identification and quantification of Caspase-3 activity in apoptotic cells. The fluorogenic AMC residue will be released by Caspase-3 activity and can be quantified in a spectrofluorometer.
The related reversible inhibitor Ac-DEVD-CHO Code: 3172-v is available as well by PeptaNova.

References:

  1. D.W. Nicholson et al, Nature, 376, 37 (1995)
  2. N.A. Thornberry et al, J. Biol. Chem, 272, 17907 (1997)

Links to publications that use our substrate Ac-Asp-Glu-Val-Asp-AMC | code 3171-v:

  1. Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation

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