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Ac-Asp-Glu-Val-Asp-AMC | Ac-DEVD-AMC

Ac-Asp-Glu-Val-Asp-MCA | Ac-DEVD-MCA

3171-v 5 mg | 72.00 EUR

Acetyl- L-aspartyl- L-glutamyl- L-valyl- L-aspartic acid α-(4-methyl- coumaryl- 7- amide)

(M.W. 675.65) C30H37N5O13 [169322-61-0]

Synthetic Product
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Selective Substrate for Caspase-3/7/8 (apopain; Yama; CPP-32)

Ac-DEVD-AMC is a selective fluoreogenic caspase substrate taken out of the sequence of the target enzyme Poly (ADP-ribose) polymerase. The fluorogenic tetrapeptide substrate Ac-DEVD-AMC is a useful tool for the identification and quantification of Caspase-3 activity in apoptotic cells. The fluorogenic AMC residue will be released by Caspase-3 activity and can be quantified in a spectrofluorometer.
The related reversible inhibitor Ac-DEVD-CHO Code: 3172-v is available as well by PeptaNova.


  1. D.W. Nicholson et al, Nature, 376, 37 (1995)
  2. N.A. Thornberry et al, J. Biol. Chem, 272, 17907 (1997)

Links to publications that use our substrate Ac-Asp-Glu-Val-Asp-AMC | code 3171-v:

  1. Human caspase-3 inhibition by Z-tLeu-Asp-H: tLeu(P2) counterbalances Asp(P4) and Glu(P3) specific inhibitor truncation


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