Ac-Tyr-Val-Ala-Asp-AMC

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Ac-Tyr-Val-Ala-Asp-AMC | Ac-YVAD-AMC

Ac-Tyr-Val-Ala-Asp-MCA | Ac-YVAD-MCA

3161-v 5 mg | 75.00 EUR

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspartic acid α-(4-methyl- coumaryl- 7-amide)

(M.W. 665.70) C33H39N5O10 [149231-65-2]

Synthetic Product
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Ac-YVAD-AMC | Substrate for Caspase-1/4

The tetrapeptide substrate with the sequence Ac-Tyr-Val-Ala-Asp-AMC | Ac-YVAD-AMC is widly used for the determination of caspase 1 activity in apoptotic cell lysates. Ac-YVAD-AMC will be cleaved by caspase 1 between the aspartic acid residue and the amino methyl cumaric acid. The released fluorogenic AMC can easily quantified by a commonly used spectrofluorometer.

References:

  1. N.A. Thornberry et al, Nature, 356, 768 (1992)

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