Ac-YVAD-CMK

165,00 € excl. 19% VAT

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SKU: 3180-v Category: Tags: ,

Ac-YVAD-CMK | Ac-Tyr-Val-Ala-Asp-CH2Cl

Ac-YVAD-Chloromethylketone

3180-v 5 mg | 165.00 EUR

Acetyl- L-tyrosyl- L-valyl- L-alanyl- L-aspart-1-yl-Chloromethane

(M.W. 541.00) C24H33N4O8Cl [178603-78-6]

Synthetic Product

Irreversible Inhibitor for Caspase-1

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CH2Cl) is used as an irreversible inhibitor for Caspase-1, instead of the pseudo acid (aldehyde) Ac-YVAD-CHO which inhibits caspase reversible. The caspase-1 inhibitor Ac-YVAD-CMK is of interest in reasearch of sepsis and endotoxic shock.

References:

  1. Y.A. Lazebnik, S.H. Kaufmann, S. Desnoyers, G.G. Poirier and W.C. Earnshaw, Nature, 371, 346 (1994)
  2. M. Enari, H. Hug and S. Nagata, Nature, 375, 78 (1995)
  3. C.E. Milligan, D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim and L.W. Schwartz, Neuron, 15, 385 (1995)
  4. E. Fujita, T. Mukasa, T. Tsukahara, K. Arahata, S. Omura and T. Momoi, Biochem. Biophys. Res. Commun, 224, 74 (1996)

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