Adrenomedullin (Human)

4278-s 0.1 mg | 205.00 EUR

Synthetic Product (Disulfide bond between Cys¹⁶-Cys²¹)

Tyr – Arg – Gln – Ser – Met – Asn – Asn – Phe – Gln – Gly – Leu – Arg – Ser – Phe – Gly – Cys – Arg – Phe – Gly – Thr – Cys – Thr – Val – Gln – Lys – Leu – Ala – His – Gln – Ile – Tyr – Gln – Phe – Thr – Asp – Lys – Asp – Lys – Asp – Asn – Val – Ala – Pro – Arg – Ser – Lys – Ile – Ser – Pro – Gln – Gly – Tyr – NH₂

The purity is guaranteed to be higher than 99% by HPLC

The biological activity of human Adrenomedullin offered by PeptaNova is examined by the Division of Pharmacology of Peptide Institute, Inc.

This product is distributed under the licence of Shionogi & Co. , Ltd. The use for any purpose other than research is strictly prohibited.

Hypotensive Peptide

Adrenomedullin was first described in 1993 as an ubiquitous peptide expressed by numbers of different cell types. It has been detected in a wide range of disease states and may play a role in some cardiovascular disorders, blood pressure regulation and inhibition of endothelial cell apoptosis. Recently it was reported that an increased plasma level of Adrenomedullin could be a potential biochemical indicator for recurrent pregnancy loss. In addition Adrenomedullin is suspected to play a role in the early stages of sepsis.
Circulating Adrenomedullin can be easily measured by ELISA using Adrenomedullin (Human) Antiserum code 14278-v

References:

1. K. Kitamura, K. Kangawa, M. Kawamoto, Y. Ishiki, S. Nakamura, H. Matsuo and T. Eto, Biochem. Biophys. Res. Commun. , 192, 553 (1993). (Original)
2. K. Kitamura, J. Sakata, K. Kangawa, M. Kojima, H. Matsuo and T. Eto, Biochem. Biophys. Res. Commun. , 194, 720 (1993). (Original; cDNA)