Alarin (Human)

80,00 € excl. 19% VAT

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SKU: 4449-s Category:

Alarin (Human)

4449-s 0.1 mg | 80.00 EUR

Ala – Pro – Ala – His – Arg – Ser – Ser – Thr – Phe – Pro – Lys – Trp – Val – Thr – Lys – Thr – Glu – Arg – Gly – Arg – Gln – Pro – Leu – Arg – Ser

(M.W. 2894.3) C127H205N43O35

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Alarin (Human) is a Splice Variant of Galanin-Like Peptide.
Alarin immunoreactivity is detected in pericytes and venules in human dermis, but not in endothelian cells of blood vessels. Alarin is reported to inhibit inflammatory edema included by substance P and CGRP at doses in picomolar range in mouse, which is a characteristic feature also observed in Galanin and GALP. In conjunction with Galanin and GALP, Alarin might be an essential tool for vascular systems research.

References:

  1. R. Santic, K. Fenninger, K. Graf, R. Schneider, C. Hauser-Kronberger, F.H. Schilling, P. Kogner, M. Ratschek, N. Jones, W. Sperl and B. Kofler, J. Mol. Neurosci., 29, 145 (2006) (Original, Alarin)
  2. R. Santic, S.M. Schmidhuber, R. Lang, I. Rauch, E. Voglas, N. Eberhard, J.W. Bauer, S.D. Brain and B. Kofler, Proc. Natl. Acad. Sci. USA., 104, 10217 (2007) (Pharmacology of Alarin)
  3. R. Lang, A.L. Gundlach and B. Kofler, Pharmacol. Ther., 115, 177 (2007) (Review)

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