Apamin

135,00 € excl. 19% VAT

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SKU: 4257-v Category: Tags: ,

Apamin
(Honeybee, Apis mellifera)

4257-v 0.5 mg | 135.00 EUR

Cys – Asn – Cys – Lys – Ala – Pro – Glu – Thr – Ala – Leu – Cys – Ala – Arg – Cys – Gln – Gln – His-NH2

(M.W. 2027.3) C79H131N31O24S4 [24345-16-2]

Synthetic Product (disulfide bond between Cys1-Cys11 and Cys3-Cys15)

The purity is guaranteed to be higher than 99% by HPLC

Apamin | Small Conductance Ca2+-activated K+ Channel Blocker

Apamin, a small basic neurotoxic peptide of 18 amino acid residues with 2 disulfide bridges, binds selectively to the Small Conductance Ca2+ channel and acts as a pore blocker for all. It was reported that Apamin can pass the blood-brain barrier. Apamin from PeptaNova is synthesized by solid phase peptide chemistry methods and not isolated from biological sources.
A second SK channel blocker, Scyllatoxin is available for prompt delivery from stock.

References:

  1. E. Haberman, Pharmacol. Ther., 25, 255 (1984) (Review)
  2. A.L. Blatz and K.L. Magleby, Nature, 323, 718 (1986) (Pharmacol.)
  3. M.L. Garcia, A. Galvez, M. Garcia-Calvo, V.F. King, J. Vazquez and G.J. Kaczorowski, J. Bioenerg. Biomembr., 23, 615 (1991) (Review)

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