Apamin

135,00  excl. 19% VAT

SKU: 4257-v Category: Tags: ,

Apamin
(Honeybee, Apis mellifera)

4257-v 0.5 mg | 135.00 EUR

Cys – Asn – Cys – Lys – Ala – Pro – Glu – Thr – Ala – Leu – Cys – Ala – Arg – Cys – Gln – Gln – His-NH2

(M.W. 2027.3) C79H131N31O24S4 [24345-16-2]

Synthetic Product (disulfide bond between Cys1-Cys11 and Cys3-Cys15)

The purity is guaranteed to be higher than 99% by HPLC

Apamin | Small Conductance Ca2+-activated K+ Channel Blocker

Apamin, a small basic neurotoxic peptide of 18 amino acid residues with 2 disulfide bridges, binds selectively to the Small Conductance Ca2+ channel and acts as a pore blocker. It was reported that Apamin can pass the blood-brain barrier and shows a dose-dependant influence on the secretion of prolactin. Apamin was originally isolated from the venom of the honeybee. The high pure peptide offered from PeptaNova is synthesized in Japan by solid phase peptide chemistry methods and is not isolated from biological sources.
A second SK channel blocker, Scyllatoxin is available for prompt delivery from stock.

References:

  1. E. Haberman, Pharmacol. Ther., 25, 255 (1984) (Review)
  2. A.L. Blatz and K.L. Magleby, Nature, 323, 718 (1986) (Pharmacol.)
  3. M.L. Garcia, A. Galvez, M. Garcia-Calvo, V.F. King, J. Vazquez and G.J. Kaczorowski, J. Bioenerg. Biomembr., 23, 615 (1991) (Review)

Links to publications that use our peptide Hepcidin-25 (LEAP-1) | code 4392-s:

  1. Functions of CaBP1 and CaBP2 in the peripheral auditory system