APF Sialoglycopeptide

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APF Sialoglycopeptide
Antiproliferative Factor Sialoglycopeptide

24007-v 50 µg | 180.00 EUR

O- (Acetamido- 3,5- dideoxy- D- glycero- α- D- galacto- 2- nonulopyranosylonic acid)- (2 →3)- O- β- D- galactopyranosyl- (1→3)- O- α- 2- acetamido- 2- deoxy- D- galactopyranosyl- (1 →O)- Thr- Val- Pro- Ala- Ala- Val- Val- Val- Ala

(M.W. 1482.60) C63H107N11O29

Synthetic Product (Ammonium Form)

Download PDF-structural formula:   pdf

Antiproliferative Factor from Interstitial Cystitis Patients

Antiproliferative Factor Sialoglycopeptide was isolated from the bladder of the patients with interstitial cystitis. APF Sialoglycopeptide exerts the following disease-related activities: 1) inhibition of normal bladder epithelial cell growth, 2) inhibition of 3H-thymidine incorporation into the same cell and 3) decrease of heparin-binding epidermal growth factor (EGF)-like growth factor production, and proliferation. The peptide without the carbohydrate moiety was found to be inactive, strongly indicating that the carbohydrate attachment onto this peptide is critical for elicting the activity.
Chemists in the division of carbohydrate chemistry at Peptide Institute, Inc. have succeded in the total synthesis of APF Sialoglycopeptide, so that this glycopeptide can be made available for our research customers concerning the pathogenesis of interstitial cystitis and ultimately for the development of a cure for this particular disease.

References:

  1. S.K. Keay, C.-O. Zhang, J. Shoenfelt, D.R. Erickson, K. Whitmore, J.W. Warren, R. Marvel and T. Chai, Urology, 57, 9 (2001)(Antiproliferative Factor from Urine of Interstitial Cystitis Patients)
  2. S.K. Keay, Z. Szekely, T.P. Conrads, T.D. Veenstra, J.J. Barchi, Jr., C.-O. Zhang, K.R. Koch and C.J. Michejda, Proc. Natl. Acad. Sci. U.S.A., 101, 11803 (2004)(Original; Structure of Antiproliferative Factor Sialoglycopeptide )
  3. C.-O.Zhang, Z.-L.Li and C.-Z.Kong, BioMed Central Urology, 5,7 (article 7 from volume 5 of the journal (Pharmacology of APF Sialoglycopeptide)

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