Beta-Defensin-1 (Human)

210,00 € excl. 19% VAT

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Beta-Defensin-1 (Human)
hBD-1 | Human β-Defensin-1

4337-s 0.1 mg | 210.00 EUR

Synthetic Product (disulfide bonds between Cys5-Cys34, Cys12-Cys27 and Cys17-Cys35)

Asp – His – Tyr – Asn – Cys – Val – Ser – Ser – Gly – Gly – Gln – Cys – Leu – Tyr – Ser – Ala – Cys – Pro – Ile – Phe – Thr – Lys – Ile – Gln – Gly – Thr – Cys – Tyr – Arg – Gly – Lys – Ala – Lys – Cys – Cys – Lys

(M.W. 3928.5) C167H256N48O50S6

The purity of Beta-Defensin-1 is guaranteed to be higher than 99% by HPLC

Novel Defensin with Broad Spectrum

The recently described group of human beta defensins represent an important family of antimicrobial peptides. Human defensins are classified in two well defined subclasses. First the group of four alpha-defensins as there is for example α-defensin-1 (HNP-1, code 4271-s) and secondly the family of beta-defensin peptides (hBD), which are defined by their disposition of three disulfide bridges.
The description of human Beta-Defensin-1 (hBD-1), code 4338-s), human beta-defensin-2 (hBD-2, code 4338-s) and human beta-defensin-3 (hBD-3) was very helpful in understanding the important role of endogenous antimicrobial peptides.

Beta-Defensin-1 (Human) is a polypeptide composed of 36 amino acid residues and three disulfide bonds. hBD-1 is produced by chemical peptide synthesis and carefully described in our analytical datasheet.

References:

  1. K.W. Bensch, M. Raida, H.J. Mägert, P. Schulz-Knappe and W.G. Forssmann, FEBS Lett., 368, 331 (1995) (Original)
  2. M.J. Goldman, G.M. Anderson, E.D. Stolzenberg, U.P. Kari, M. Zasloff and J.M. Wilson, Cell, 88, 553 (1997) (Pharmacol; Inactivated in Cystic Fibrosis)
  3. T. Hiratsuka, M. Nakazato, T. Ihi, T. Minimatsu, N. Chino T. Nakanishi, A. Shimizu, K. Kangawa and S. Matsukura, Nephron, 85, 34 (2000) (Pharmacology of beta-Defensin-1)

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