Big Endothelin-1 (Human, 1 – 38)
Big ET-1 (1-38) (human)

4208-v 0.5 mg | 425.00 EUR

Synthetic Product (disulfide bonds between Cys¹-Cys¹⁵ and Cys³-Cys¹¹)

Cys – Ser – Cys – Ser – Ser – Leu – Met – Asp – Lys – Glu – Cys – Val – Tyr – Phe – Cys – His – Leu – Asp – Ile – Ile – Trp – Val – Asn – Thr – Pro – Glu – His – Val – Val – Pro – Tyr – Gly – Leu – Gly – Ser – Pro – Arg – Ser

The purity is guaranteed to be higher than 99% by HPLC

The biological activity of Big Endothelin-1 (Human, 1 – 38) is examined by the Division of Pharmacology, Peptide Institute, Inc.

So called Big Endothelin is the precursor for Endothelin-1 and is cleaved by Endothelin-converting enzyme-1

A specific
Antiserum for Big Endothelin-1 (Human, 1-38) is available by PeptaNova.

For Laboratory use only! Not for Drug Use!

References:

1. Y. Ito, M. Yanagisawa, S. Ohkubo, C. Kimura, T. Kosaka, A. Inoue N. Ishida, Y. Mitsui, H. Onda, M. Fujino and T. Masaki, FEBS Lett., 231, 440 (1988) (Original)
2. T. Kashiwabara, Y. Inagaki, H. Ohta, A. Iwamatsu, M. Nomizu, A. Morita, and K. Nishikori, FEBS Lett., 247, 73 (1989) (Pharmacol.)

Big Endothelin-1 (Human, 1 – 38) is distributed through Peptide Institute, Inc. under the license of Takeda Pharmaceutical Company, Ltd.