Biotinyl-Asp-Glu-Val-Asp-H (aldehyde)

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SKU: 3173-v Category:

Biotinyl-DEVD-CHO | Biotinyl-Asp-Glu-Val-Asp-H (aldehyde)

3173-v 1 mg | 85.00 EUR

Biotin- L-aspartyl- L-glutaminyl- L-threonyl- L-aspart-1-al

(M.W. 686.74) C28H42N6O12S [178603-73-1]

Synthetic Product

Biotinyl-DEVD-CHO – synthetic inhibitor for Caspase-3/7/8

References:

  1. D.W. Nicholson, A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnik, N.A. Munday, S.M. Raju, M.E. Smulson, T.-T. Yamin, V.L. Yu and D.K. Miller, Nature, 376, 37 (1995)

The inhibitory activity of this biotinylated apopain inhibitor (Biotinyl-DEVD-CHO) is comparable to that of his N-acetylated analog Ac-DEVD-CHO (IC50 = 0.2 nM). Our inhibitor Biotinyl-Asp-Glu-Val-Asp-H (aldehyde) can be used for affinity purification of caspase-3 (apopain) on streptavidin-agarose columns.

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