Calcicludine

255,00 € excl. 19% VAT

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SKU: 4310-s Category:

Calcicludine
CaC (Green Mamba, Dendroapsis angusticeps)

4310-s 0.1 mg | 255.00 EUR

Trp – Gln – Pro – Pro – Trp – Tyr – Cys – Lys – Glu – Pro – Val – Arg – Ile – Gly – Ser – Cys – Lys – Lys – Gln – Phe – Ser – Ser – Phe – Tyr – Phe – Lys – Trp – Thr – Ala – Lys – Lys – Cys – Leu – Pro – Phe – Leu – Phe – Ser – Gly – Cys – Gly – Gly – Asn – Ala – Asn – Arg – Phe – Gln – Thr – Ile – Gly – Glu – Cys – Arg – Lys – Lys -Cys – Leu – Gly – Lys

(M.W. 6980.1) C321H476N86O78S6

Synthetic Product (disulfide bonds between Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53 )

The purity is guaranteed to be higher than 99% by HPLC

Calcicludine is a neuronal L-type Ca2+ Channel Blocker and was originally isolated from the green mamba venom. Calcicludine shows a structure-activity relationship to Dendrotoxin I

The biological activity of Calcicludine is examined by the Division of Pharmacology, Peptide Institute, Inc.

References:

  1. H. Schweitz, C. Heurteaux, P. Bois, D. Moinier, G. Romey and M. Lazdunski, Proc. Natl. Acad. Sci. USA, 91, 878 (1994) (Original)
  2. H. Nisho, J. Nishiuchi, T. Inui, M. Nakao, T.X. Watanabe, T. Kimura and S. Sakakibara, Peptide Chemistry, 1985, 113 (1996) (Chem. Synthesis of Calcicludine and Pharmacology)
  3. O.D. Uchitel, Toxicon, 35, 1161 (1997) (Review)

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