Calcicludine
CaC (Green Mamba, Dendroapsis angusticeps)

4310-s 0.1 mg | 255.00 EUR

Trp – Gln – Pro – Pro – Trp – Tyr – Cys – Lys – Glu – Pro – Val – Arg – Ile – Gly – Ser – Cys – Lys – Lys – Gln – Phe – Ser – Ser – Phe – Tyr – Phe – Lys – Trp – Thr – Ala – Lys – Lys – Cys – Leu – Pro – Phe – Leu – Phe – Ser – Gly – Cys – Gly – Gly – Asn – Ala – Asn – Arg – Phe – Gln – Thr – Ile – Gly – Glu – Cys – Arg – Lys – Lys -Cys – Leu – Gly – Lys

Synthetic Product (disulfide bonds between Cys⁷-Cys⁵⁷, Cys¹⁶-Cys⁴⁰ and Cys³²-Cys⁵³ )

The purity is guaranteed to be higher than 99% by HPLC

Calcicludine is a neuronal L-type Ca²⁺ Channel Blocker and was originally isolated from the green mamba venom. Calcicludine shows a structure-activity relationship to Dendrotoxin I

The biological activity of Calcicludine is examined by the Division of Pharmacology, Peptide Institute, Inc.

References:

1. H. Schweitz, C. Heurteaux, P. Bois, D. Moinier, G. Romey and M. Lazdunski, Proc. Natl. Acad. Sci. USA, 91, 878 (1994) (Original)
2. H. Nisho, J. Nishiuchi, T. Inui, M. Nakao, T.X. Watanabe, T. Kimura and S. Sakakibara, Peptide Chemistry, 1985, 113 (1996) (Chem. Synthesis of Calcicludine and Pharmacology)
3. O.D. Uchitel, Toxicon, 35, 1161 (1997) (Review)