Calciseptine

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SKU: 4255-s Category:

Calciseptine
(Black Mamba, Dendroaspis polylepis polylepis)

4255-s 0.1 mg | 255.00 EUR

Arg – Ile – Cys – Tyr – Ile – His – Lys – Ala – Ser – Leu – Pro – Arg – Ala – Thr – Lys – Thr – Cys – Val – Glu – Asn – Thr – Cys – Tyr – Lys – Met – Phe – Ile – Arg – Thr – Gln – Arg – Glu – Tyr – Ile – Ser – Glu – Arg – Gly – Cys – Gly – Cys – Pro – Thr – Ala – Met – Trp – Pro – Tyr – Gln – Thr – Glu – Cys – Cys – Lys – Gly -Asp – Arg – Cys – Asn – Lys

(M.W. 7036.1) C299H468N90O87S10 [134710-25-1]

Synthetic Product (disulfide bonds between Cys3-Cys22, Cys17-Cys39Cys41-Cys52 and Cys43-Cys58 )

The purity is guaranteed to be higher than 99% by HPLC

L-type Ca2+ Channel Blocker

The biological activity of Calciseptine is examined by the Division of Pharmacology, Peptide Institute, Inc.

Calciseptine is a neuropeptide toxin originally isolated from the venom of the african snake Black Mamba (Dendroaspis polylepis polylepis). It is an unusually great peptide toxin with a molweight greater than 7k. Calciseptine blocks specifically L-type Ca2+ channels and shows no activity against N-type and T-type Ca2+ channels. On the other hand, Calciseptine blocks spontaneous K+-induced contraction of cardiac and smooth muscle cells.
Calciseptine purchased from PeptaNova is a synthetic peptide manufactured by Peptide Institute, Inc.

References:

  1. J.R. DeWeille, H. Schwetz, P. Maes, A. Tartar and M. Lazdunski, Proc. Natl. Acad. Sci. USA, 88, 2437 (1991) (Original Description of Calciseptine)
  2. H. Kuroda, Y.N. Chen, T.X. Watanabe, T. Kimura and S. Sakakibara, Pept. Res., 5, 265 (1992) (Chem. Synthesis of Calciseptine)
  3. T.X. Watanabe, Y. Itahara, H. Kuroda, Y.N. Chen, T. Kimura and S. Sakakibara, Jpn. J. Pharmacol., 68, 305 (1995) (Pharmacology of Calciseptine)
  4. N. Teramoto, R. Ogata, K. Okabe, A. Kameyama, M. Kamayama, T.X. Watanabe, H. Kuriyama and K. Kitamura, Pflügers Arch., 432, 462 (1996) (Pharmacol)

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