E-64-c

82,00 € excl. 19% VAT

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E-64-c

4320-v 5 mg | 82.00 EUR

[(2S,3S)-3-carboxyoxirane-2-carbonyl]-L-Leucine (3-Methylbutyl)amide
L-trans-Epoxysuccinyl-Leu-3-methylbutylamide

(M.W. 314.38) C15H26N2O5 [76684-89-4]

Synthetic Product

Inhibitor for Thiol Protease (Cathepsin B/H/L)

E-64-c a synthetic analog of E-64 is a membrane-impermeable calpain inhibitor, where as the ethyl ester of E-64-c ( E-64-d) shows good membrane permeability.
E-64c inhibits Cathepsins more quickly than the commonly used inhibitor E-64.

References:

  1. S. Hashida, T. Towatari, E. Kominami and N. Katunuma, J. Biochem., 88, 1805 (1980) (Original; IC50)
  2. M. Tamai, K. Hanada, T. Adachi, K. Oguma, K. Kashiwagi, S. Omura, and M. Ohzeki, J. Biochem., 90, 255 (1981) (Chem. Structure & Biochemistry of E-64-c)
  3. A.J. Barrett, A.A. Kembhavi, M.A. Brown, H. Kirschke, C.G. Knight, M. Tamai, and K. Hanada, Biochem. J., 201, 189 (1982) (Biochem.)
  4. K. Suzuki, J. Biochem., 93, 1305 (1983) (Biochem.)

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