Fmoc-Cys(Dpm)

105,00  excl. 19% VAT

Fmoc-Cys(Dpm)

2329 5 g | 105.00 EUR

9-Fluorenylmethoxycarbonyl-S-diphenyl-L-cysteine

(M.W. 509.62) C31H27NO4S 247595-29-5

Synthetic Product

Fmoc-protected cysteine derivative for regio selective disulfide construction in combination with Fmoc-Cys(Trt)

The diphenyl (Dpm) group is helpful to prevent the risk of racemization during the incorporation of the Cys residue. Fmoc-Cys(Dpm) is fully compatible with Fmoc-Cys(Trt) for regio selective disulfide construction because the Dpm group requires 60% TFA for cleavage where as the trityl group is cleaved with 10 % TFA.

References:

  1. M. Góngora-Benítez, L. Mendive-Tapia, I. Ramos-Tomillero, A.C. Breman, J. Tulla-Puche and F. Albericio, Org. Lett., 14, 5472(2012)
  2. H. Hibino, Y. Miki and Y. Nishiuchi, J. Pept. Sci., 20, 30(2014)