Fmoc-His(MBom)

145,00 € excl. 19% VAT

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Fmoc-His(MBom)

2328 1 g | 145.00 EUR
2328 5 g | 585.00 EUR

Nα-9-Fluorenylmethoxycarbonyl-Nπ-4-methoxybenzyloxymethyl-L-histidine

(M.W. 527.57) C30H29N3O6 1327338-56-6

Synthetic Product

New histidine derivative to minimize racemisation risk

The 4-methoxybenzyloxymethyl (MBom) group at the Nπ-position of histidine is explicitly designed for conventional and microwave assisted Fmoc-SPPS. Fmoc-His(MBom) is a useful Fmoc-derivative to suppress the racemization during the coupling process of the His residue.

References:

  1. H. Hibino, and Y. Nishiuchi, Tetrahedron Lett., 52, 4947(2011)
  2. H. Hibino, Y. Miki, and Y. Nishiuchi, J. Pept. Sci., 18, 763(2012)
  3. K. Sakamoto, K. Sato, A. Shigenaga, K. Tsuji, S. Tsuda, H. Hibino, Y. Nishiuchi and A. Otaka, J. Org. Chem., 77, 6948(2012)

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