Galanin-like Peptide (Human, 1-60)

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Galanin-like Peptide (Human, 1-60)
GALP (Human, 1 – 60)

4391-s 0.1 mg | 215.00 EUR

Ala – Pro – Ala – His – Arg – Gly – Arg – Gly – Gly – Trp – Thr – Leu – Asn – Ser – Ala – Gly – Tyr – Leu – Leu – Gly – Pro – Val – Leu – His – Leu – Pro – Gln – Met – Gly – Asp – Gln – Asp – Gly – Lys – Arg – Glu – Thr – Ala – Leu – Glu – Ile – Leu – Asp – Leu – Trp – Lys – Ala – Ile – Asp – Gly – Leu – Pro – Tyr – Ser – His – Pro – Pro – Gln – Pro – Ser

(M.W. 6500.3) C292H451N83O84S

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Ligand for Galanin Receptor 2 / Target Peptide for Feeding Regulation by Leptin

The biological activity of Galanin-like Peptide (Human, 1 – 60) is examined by the Division of Pharmacology, Peptide Institute, Inc.

Galanin-Like Peptide (GALP) was identified as a new Feeding-Regulating Peptide and it is involved in metabolism and reproduction in the central nervous system. GALP shows additionally effects on luteinizing hormone secretion and stimulates vasopressin, oxytocin and adrenocorticotropic hormone release in rats.

Galanin-Like Peptide (GALP) | A Novel Specific Antagonist for Galanin Receptor Subtype 2

Galanin (Human) code 4245-v and Galanin (rat) code 4244-v are members of the brain-gut peptides having various biological activities including feeding regulation. This peptide is known to be a food intake stimulator which interacts with both of the galanin receptor subtypes 1 and 2 (GalR1 and GalR2, respectively) although in a relatively non-selective manner. GalR1 is primarily expressed in the central nervous system (CNS), whereas Gal2R is expressed in both peripheral tissue and the CNS.

In 1999, scientists at Takeda Chemical Industries, Ltd. discovered the GalR2-selective ligand in porcine hypothalamus. At the same time, they proposed the primary structures of the rat and human orthologues from the corresponding cDNA sequences [J. Biol. Chem., 274, 37041 (1999)]. This newly identified peptide, known as galanin-like peptide (GALP) is composed of 60 amino acid residues. Also, GALP (9-21) is identical to galanin (1-13) and the sequence homology among the species is high. When 125I-labeled rat galanin is used as a ligand, porcine Galanin-like Peptide interacts with GalR2 with an IC50 value of 0.24 nM, while the corresponding value for GalR1 is 4.3 nM, clearly indicating the receptor selectivity of Galanin-like Peptide. Since then, additional data concerning the role of rat GALP in feeding have been reported dealing with:

  1. stimulation of food intake in rats [Neurosci. Lett., 322, 67 (2002)],
  2. control of its expression by leptin [Endocrinology, 141, 2703 (2000)], and
  3. crossing the blood brain barrier [Neuroendocrinology, 74, 423 (2001)].

Recently a review article concerning the function of Galanin-like Peptide in relation to galanin and the galanin receptor has also been published [Eur. J. Pharmacol., 440, 255 (2002), Clin. Exp. Pharmacol. Physiol., 28, 100 (2001)]. Although extensive research has not yet been performed with the human peptide, Galanin-like Peptide appears to be an essential peptide for understanding the feeding control mechanism.

References:

  1. T. Ohtaki, S. Kumano, Y. Ishibashi, K. Ogi, H. Matsui, M. Harada, C. Kitada, T. Kurokawa, H. Onda and M. Fujino, J. Biol. Chem., 274, 37041 (1999) (Original)
  2. A. Juréus, M.J. Cunningham, M.E. Mcclain, D.K. Clifton and R.A. Steiner, Endocrinology., 141, 2703 (2000) (Pharmacol.)
  3. Y. Matsumoto, T. Watanabe, Y. Adachi, T. Itoh, T. Ohtaki, H. Onda, T. Kurokawa, O. Nishimura and M. Fujino, Neurosci. Lett., 322, 67 (2002) (Stimulation of Food Intake)
  4. A.L. Gundlach, Eur. J. Pharmacol., 440, 255 (2002) (Review)
  5. A.J. Kastin, V. Akerstrom and L. Hackler, Neuroendocrinology., 74, 423 (2001) (Brain Entry)

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