Guanylin (Human)

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SKU: 4274 Category:

Guanylin (Human)

4274-s 0.1 mg 85.00 EUR
4274 5 x 0.1 mg 345.00 EUR

Pro-Gly-Thr-Cys-Glu-Ile-Cys-Ala-Tyr-Ala-Ala-Cys-Thr-Gly-Cys

(M.W. 1458.7) C58H87N15O21S4

Synthetic Product (disulfide bonds between Cys4-Cys12 and Cys7-Cys15)

The purity is guaranteed to be higher than 99% by HPLC

Guanylin is an endogenous intestinal peptide and acts as a common Guanylate Cyclase C Activator. It is part of the regulation of water and electrolyte secretion by intestinal mucosa. Guanylin has structural similarity to bacterial peptides who cause diarrhoea.

References:

  1. R.C. Wiegand, J. Kato, M.D. Huang, K.F. Foc, J.F. Kachur and M.G. Currie, FEBS Lett., 311, 150 (1992) (Original; cDNA)
  2. F.J. de Sauvage, S. Keshav, W.-J. Kuang, N. Gillett, W. Henzel and D.V. Goeddel, Proc. Natl. Acad. Sci. USA, 89, 9089 (1992) (Original; cDNA)
  3. M. Kuhn, M. Raida, K. Adermann, P. Schulz-Knappe, R. Gerzer, J.-M. Heim, and W.-G. Forssmann, FEBS Lett., 318, 205 (1993) (Guanylin |Circulating Form)
  4. O. Hill, M. Kuhn, H.-D. Zucht, Y. Cetin, H. Kulaksiz, K. Adermann, G. Klock, G. Rechkemmer, W.-G. Forssmann and H.-J. Maegert, Proc. Natl. Acad. Sci. USA., 92, 2046 (1995) (Immunohistochemistry of Guanylin)

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