Huwentoxin-IV

165,00 € excl. 19% VAT

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SKU: 4455-s Category:

Huwentoxin-IV
HWTX-IV
(Chinese Bird Spider, Ornithoctonus huwena)

4455-s 0.1 mg | 165.00 EUR

Glu – Cys – Leu – Glu – Ile – Phe – Lys – Ala – Cys – Asn – Pro – Ser – Asn – Asp – Gln – Cys – Cys – Lys – Ser – Ser – Lys – Leu – Val – Cys – Ser – Arg – Lys – Thr – Arg – Trp – Cys – Lys – Tyr – Gln – Ile – NH2

(M.W. 4106.8) C174H278N52O51S6

Synthetic Product (Disulfide bonds between Cys2 – Cys17, Cys9 – Cys24, and Cys16 – Cys31)

The purity of our product Huwentoxin-IV is guaranteed to be higher than 99% by HPLC

Neuronal Tetrodotoxin-Sensitive Na+-Channel Blocker

Huwentoxin-IV, HWTX-IV) was originally isolated from the Chinese Bird Spider venom. The 35 residue peptide build 3 disulfid bridges and is a potent inhibitor of neuronal voltage gated sodium channels.

References:

  1. K. Peng, Q. Shu, Z. Liu and S. Liang, J. Biol. Chem., 277, 47564 (2002) (Original)
  2. J. Diao, Y. Lin, J. Tang and S. Liang, Toxicon, 42, 715 (2003) (cDNA Seq.)
  3. Y. Xiao, J.-P. Bingham, W. Zhu, E. Moczydlowski, S. Liang and T.R. Cummins, J. Biol. Chem., 283, 27300 (2008) (Pharmacology)
  4. Y. Xiao, X. Luo, F. Kuang, M. Deng, M. Wang, X. Zeng and S. Liang, Toxicon, 51, 230 (Pharmacol.)

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