Iberiotoxin

145,00 € excl. 19% VAT

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Iberiotoxin
IbTX
(Scorpion, Buthus tamulus)

4235-s 0.1 mg | 145.00 EUR

Pyr – Phe – Thr – Asp – Val – Asp – Cys – Ser – Val – Ser – Lys – Glu – Cys – Trp – Ser – Val – Cys – Lys – Asp – Leu – Phe – Gly – Val – Asp – Arg – Gly – Lys – Cys – Met – Gly – Lys – Lys – Cys – Arg – Cys – Tyr – Gln

(M.W. 4230.8) C179H274N50O55S7 [129203-60-7]

Synthetic Product (disulfide bonds between Cys7-Cys28, Cys13-Cys33 and Cys17-Cys35)

The purity of IbTX is guaranteed to be higher than 99% by HPLC

Iberiotoxin (IbTX), originally isolated from the venom of the scorpion buthus tamulus, is a potent Ca2+-activated K+ Channel Blocker (Maxi-K+ Channel Blocker). IbTX offered from PeptaNova is a chemically manufactured peptide and not isolated from animal origin or from recombinant sources.

The biological activity of Iberiotoxin (IbTX) is examined by the Division of Pharmacology, Peptide Institute, Inc.

Shipping | Storage | Stability
Iberiotoxin (IbTX) will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing.

References:

  1. A. Galvez, G. Gimenez-Gallego, J.P. Reuben, L. Roy-Contancin, P. Feigenbaum, G.J. Kaczorowski and M.L. Garcia, J. Biol. Chem., 265, 11083 (1990) (Original)
  2. M.L. Garcia, A. Galvez, M. Garcia-Calvo, V.F. King, J. Vazquez and G. J. Kaczorowski, J. Bioenerg. Biomembr., 23, 615 (1991) (Review)
  3. K.M. Giangiacomo, M.L. Garcia and O.B. McManus, Biochemistry., 31, 6719 (1992) (Pharmacol.)
  4. K.G. J. Kaczorowski, H.-G. Kaus, R.J. Leonard, O.B. McManus and M.L. Garcia, J. Bioenerg. Biomembr., 28, 255 (1996) (Review, Iberiotoxin)

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