Kaliotoxin (1-37)

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SKU: 4259-s Category:

Kaliotoxin (1-37)
(Scorpion, Androctonus mauretanicus mauretanicus)

4259-s 0.1 mg | 160.00 EUR

Kaliotoxin (1-37) is a high conductance Ca2+- activated K+ Channel Blocker

Gly – Val – Glu – Ile – Asn – Val – Lys – Cys – Ser – Gly – Ser – Pro – Gln – Cys – Leu – Lys – Pro – Cys – Lys – Asp – Ala – Gly – Met – Arg – Phe – Gly – Lys – Cys – Met – Asn – Arg – Lys – Cys – His – Cys – Thr – Pro

(M.W. 4021.8) C165H271N53O48S8

Synthetic Product (disulfide bonds between Cys8-Cys28, Cys14-Cys33 and Cys18-Cys35)

The purity is guaranteed to be higher than 99% by HPLC

The peptide toxin Kaliotoxin (1-37) was originaly isolated from the venom of an african scorpion and shows significiant sequence homology to Iberiotoxin and Charybdotoxin.

References:

  1. M. Crest, G. Jacquet, M. Gola, H. Zerrouk, A. Benslimane, H. Rochat, P. Mansuelle and M.-F. Martin-Eauclaire, J. Biol. Chem., 267, 1640 (1992) (Original)
  2. R. Romi, M. Crest, M. Gola, F. Sampieri, G. Jacquet, H. Zerrouk, P. Mansuelle, O. Sorokine, A.V. Dorsselaer, H. Rochat, M.-F. Martin-Eauclaire and J.V. Rietschoten, J. Biol. Chem., 268, 26302 (1993) (Pharmacol)
  3. F.R. Romi, S. Szendeffy, M.F. Martin-Eauclaire, H. Rochat, J.V. Rietschoten, M. Pons and E. Giralt, Biochemistry, 33, 14256 (1994) (Unique structure)
  4. A.L. Harvey, H. Vatanpour, E.G. Rowan, S. Pinkasfeld, C. Vita, A. Menez and M.-F. Martin-Eauclaire, Toxicon, 33, 425 (1995) (Pharmacol.)

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