Kurtoxin

240,00 € excl. 19% VAT

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SKU: 4375-s Category:

Kurtoxin
(Scorpion, Parabuthus transvaalicus)

4375-s 0.1 mg | 240.00 EUR

Lys – Ile – Asp – Gly – Tyr – Pro – Val – Asp – Tyr – Trp – Asn – Cys – Lys – Arg – Ile – Cys – Trp – Tyr – Asn – Asn – Lys – Tyr – Cys – Asn – Asp – Leu – Cys – Lys – Gly – Leu – Lys – Ala – Asp – Ser – Gly – Tyr – Cys – Trp – Gly – Trp – Thr – Leu – Ser – Cys – Tyr – Cys – Gln – Gly – Leu – Pro – Asp – Asn – Ala – Arg – Ile – Lys – Arg – Ser – Gly – Arg – Cys – Arg – Ala

(M.W. 7386.4) C324H478N94O90S8

Synthetic Product
disulfide bonds between Cys12 – Cys61, Cys16 – Cys37, Cys23 – Cys44 and Cys27 – Cys46

The purity of Kurtoxin is guaranteed to be higher than 99% by HPLC

T-type Ca2+ Channel Blocker

Kurtoxin, a very interesting channel blocker, from T-Type, is described as a complex peptide built of 63 amino acids and four disulfide bridges. Kurtoxin inhibits partially N- and L-type ion channels as well as P-Type and T-Type ion channels and binds to voltage-gated Na+ channels and slows their inactivation. Our peptide toxin Kurtoxin was originally isolated from the venom of the african scorpion Parabuthus transvaalicus and is a synthetic peptide, carefully manufactured from Peptide Institute, Inc.

Shipping | Storage | Stability
Our product Kurtoxin will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

  1. R.S-I. Chuang, H. Jaffe, L. Cribbs, E. Perez-Reyes and K.J. Swartz, Nat. Neurosci., 1, 668 (1998) (Original description of Kurtoxin)
  2. S.S. Sidach and I.M. Mintz, J. Neurosci., 22, 2023 (2002) (Pharmacology and Specificity for Ca2+-Channel Blocking Activity of Kurtoxin)

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