Lactacystin

155,00 € excl. 19% VAT

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SKU: 4368-v Category:

Lactacystin

4368-v 0.2 mg | 155.00 EUR

N-Acetyl- L-Cysteine- S- [(2R,3S,4R)- 3-Hydroxy- 2- [(1S)- 1- Hydroxy- 2- Methylpropyl]- 4- Methyl- 5- Oxo- 2-Pyrrolidinecarbonyl]

(M.W. 376.43) C15H24N2O7S [133343-34-7]

Microbial Product

Inhibitor for Proteasome

Lactacystin, a freeze dried microbial product is soluble in Water, DMF, DMSO, Acetonitril or Alcohol. This inhibitor can be easily prepared as a 10 mM stock solution in DMSO and stored at – 80 °C.
Cardiological experiments indicated positive effects of Lactacystine on migration and growth of vascular smooth muscle cells. The proteasome inhibitors
Z-Leu-Leu-Leu-H [MG-132] and Lactacystine where described as potent inhibitors for the degradation of 1–512 HDC. It is reported that Lactacystin may induce Apoptosis in monoblastoma cells.

References:

  1. S. Omura, T. Fujimoto, K. Otoguro, K. Matsuzaki, R. Moriguchi, H. Tanaka and Y. Sasaki, J. Antibiotics, 44, 113 (1991) (Original)
  2. G. Fenteany, R.F. Standaert, W.S. Lane, S. Choi, E.J. Corey and S.L. Schreiber, Science, 268, 726 (1995) (Biochem.; Proteasome Inhibition by Lactacystin)
  3. S. Imajoh-Ohmi, T. Kawaguchi, S. Sugiyama, K. Tanaka, S. Omura and H. Kikuchi, Biochem. Biophys. Res. Commun, 217, 1070 (1995) (Biochem.; Apoptotic Effect of Lactacystin)
  4. D. Leung, G. Abbenante and D.P. Fairlie, J. Med. Chem., 43, 305 (2000)

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