Leupeptin

85,00 € excl. 19% VAT

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Leupeptin

4041-v 0.5 mg | 35.00 EUR

Acetyl- L-leucyl- L-leucyl- L-argininal (Sulfate Form)

(M.W. 426.56) C20H38N6O4 [55123-66-5]

 

4041-25 25 mg 85.00 EUR
4041-100 100 mg 175.00 EUR

 

Acetyl- L-leucyl- L-leucyl- L-argininal · ½H2SO4 · H2O

(M.W. 426.56 · 49.04 · 18.02) C20H38N6O4· ½H2SO4 · H2O [103476-89-73]

Microbial Product

Download PDF-data-sheet pdf

Inhibitor for Trypsin, Plasmin, Papain, and Cathepsin B

Leupeptin, is a microbial product, isolated and carefully purified as hemisulfate.
Leupeptin is a competitive transition state inhibitor and is mainly used as inhibitor for serine proteinases like trypsin, plasmin and kallikrein. It inhibits cysteine proteinases like papain and cathepsin B. Leupeptin does not inhibit thrombin or α-chymotypsin.
The tripeptide aldehyde is highly soluble in commonly used buffers containing Water, Ethanol, or DMF. Leupeptin will be used very often in combination with Pepstatin A in protease inhibitor cocktails like “Mito Buffer” or “TNC Buffer”.
The purity of the tripeptide aldehyde Leupeptin cannot be determined by HPLC or TLC due to three tautomeric isomers, which will be separately detected.

Shipping | Storage | Stability
Our product Leupeptin will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Please avoid repeated freezing and thawing by preparing aliquots.
Aqueous stock solutions of Leupeptin are usually set up with a concentration of 1 mg/ml and should be stored at -20°C. Storage of stock solutions of Leupeptin at 4°C are possible for approx. 1 week.

References:

  1. S. Kondo, K. Kawamura, J. Iwanaga, M. Hamada, T. Aoyagi, K. Maeda, T. Takeuchi and H. Umezawa, Chem. Pharm. Bull, 17, 1896 (1969) (Biological Activity)
  2. T. Aoyagi, T. Takeuchi, A. Matsuzaki, K. Kawamura, S. Kondo, M. Hamada, K. Maeda, and H. Umezawa, J. Antibiotics, 22, 283 (1969) (Original)
  3. T. Aoyagi, T. Takeuchi, A. Matsuzaki, K. Kawamura, S. Kondo, M. Hamada, K. Maeda and H. Umezawa, J. Antibiotics, 22, 558 (1969) (Biological Activity)
  4. R.M. McConnell, J.L. York, D. Frizzell and C. Ezell, J. Med. Chem., 36, 1084 (1993) (Inhibitory Activity)
  5. D. Leung, G. Abbenante and D.P. Fairlie, J. Med. Chem., 43, 305 (2000)
  6. R. Frlan and S. Gobec, Curr. Med. Chem., 13, 2309 (2006)

Links to publications that use our inhibitor Leupeptin | code 4041:

  1. Signaling Pathways of the TREM-1- and TLR4-Mediated Neutrophil Oxidative Burst

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