Margatoxin

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SKU: 4290-s Category:

Margatoxin
MgTX
(Scorpion, Centruroides margaritatus)

4290-s 0.1 mg | 165.00 EUR

Thr – Ile – Ile – Asn – Val – Lys – Cys – Thr – Ser – Pro – Lys – Gln – Cys – Leu – Pro – Pro – Cys – Lys – Ala – Gln – Phe – Gly – Gln – Ser – Ala – Gly – Ala – Lys – Cys – Met – Asn – Gly – Lys – Cys – Lys – Cys – Tyr – Pro – His

(M.W. 4178.9) C178H286N52O50S7 [145808-47-5]

Synthetic Product (disulfide bonds between Cys7– Cys29, Cys13– Cys34, and Cys17– Cys36)

The purity of MgTX is guaranteed to be higher than 99% by HPLC. Margatoxin | MgTX offered from PeptaNova is a chemically synthesized peptide and not isolated from animal origin or expressed in E.Coli by recombinant methods. Therefore no cross contamination with foreign proteins must be expected.

Iberiotoxin – a second high selective potassium channel blocker is available for prompt delivery

Voltage-Dependent K+ Channel Blocker (Specific for Kv1.3 Channel)

Shipping | Storage | Stability
Margatoxin will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing.

References:

  1. R.J. Leonard, M.L. Garcia, R.S. Slaughter and J.P. Reuben, Proc. Natl. Acad. Sci. USA, 89, 10094 (1992) (Pharmacol.)
  2. M. Garcia-Calvo, R.J. Leonard, J. Novick, S.P. Stevens, W. Schmalhofer, G.J. Kaczorowski and M.L. Garcia, J. Biol. Chem., 268, 18866 (1993) (Original)
  3. M.A. Bednarek, R.M. Bugianesti, R.J. Leonard and J.P. Felix, Biochem. Biophys. Res. Commun., 198, 619 (1994) (Chem. Synthesis & S-S Bond of Margatoxin)
  4. H.G. Knaus, R.O.A. Koch, A. Eberhart, G.J. Kaczorowski, M.L. Garcia and R.S. Slaughter, Biochemistry, 34, 13627 (1995) (Pharmacol. of MgTx)

Links to publications that use our peptide Margatoxin (MgTx) | code 4290-s:

  1. Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production
  2. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice

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