Mca-Lys-Pro-Leu-Gly-Leu-Dap(DNP)-Ala-Arg-NH2

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Mca-Lys-Pro-Leu-Gly-Leu-Dap(DNP)-Ala-Arg-NH2

Mca-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2
MocAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2

3226-v 1 mg | 80.00 EUR

(7-Methoxycoumarin-4-yl)acetyl- L-lysyl- L-prolyl- L-leucyl- glycyl- L-leucyl- [Nβ-(2,4- dinitrophenyl)- L-2,3-diaminopropionyl]- L-alanyl- L-arginine amide

(M.W. 1221.30) C55H80N16O16

Synthetic Product (Trifluoracetate Form)
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Fluorescence-Quenching Substrate for Matrix Metalloproteinases and ADAM-17 / Tumor Necrosis Factor Converting Enzyme (TACE)

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is a commonly used Fluorescence-Quenching Substrate from MCA / DNP type.

A2pr is used in Japan as synonym for Dap = 2,3-Diaminopropionic acid (2,3-Diaminopropanoic acid)
MocAc is used in Japan as synonym for Mca = (7-Methoxycoumarin-4-yl)acetic acid.

References:

  1. U. Neumann, H. Kubota, K. Frei, V. Ganu and D. Leppert, Anal. Biochem., 328, 166 (2004)
  2. A. Trifilieff, C. Walker, T. Keller, G. Kottirsch and U. Neumann, Br. J. Pharmacol., 135, 1655 (2002)
  3. M.C. Riitano, H. Pfister, P. Engelhardt, U. Neumann, M. Reist, A. Zurbriggen, M. Stoffel, J. Peel, T. Jungi, P. Schawalder and D.E. Spreng, Am. J. Vet. Res., 63, 1423 (2002)

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