Neuromedin C

32,50 € excl. 19% VAT

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SKU: 4153 Category:

Neuromedin C
Gastrin Releasing Peptide (18-27, Human)
GRP (18-27) (Human, Porcine, Canine)

4153-v 0.5 mg | 32.50 EUR
4153-1 mg | 49.50 EUR

Gly – Asn – His – Trp – Ala – Val – Gly – His – Leu – Met – NH2

(M.W. 1120.3) C50H73N17O11S

4153-25 mg | 495.00 EUR

Gly – Asn – His – Trp – Ala – Val – Gly – His – Leu – Met – NH2 · 2AcOH · 5H2O

(M.W. 1120.3) · 120.10 · 90.08 C50H73N17O11S · 2CH3COOH · 5H2O

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

The biological activity of this peptide is examined by the Division of Pharmacology, Peptide Institute, Inc.

The decapeptide Neuromedin C was initally isolated from porcine spinal cord and canine intestinal muscle. It is identical with the gastrin-releasing peptide (GRP 18-27) and shows bombesin-like activities as well. Neuromedin-C acts as stimulator of amylase release in the same mannor as GRP-27 but Neuromedin-C was twofold more potent.

References:

  1. K.A. Roth, C.J. Evans, R.G. Lorenz, E. Weber, J.D. Barchas and J.K. Chang, Biochem. Biophys. Res. Commun., 112, 528 (1983) (Original; GRP (18-27))
  2. N. Minamino, K. Kangawa, and H. Matsuo, Biochem. Biophys. Res. Commun., 119, 14 (1984) (Original; Porcine Neuromedin C)
  3. M.S. Orloff, J.R. Reeve Jr., C.M. Ben-Avram, J.E. Shively and J.H. Walsh, Peptides, 5, 8657 (1984) (Isolation & Seq.; Human Bombesin-like Peptide)
  4. J.R. Reeve Jr., H. Walsh, P. Chew, B. Clark, D. Hawke and J.E. Shively, J. Biol. Chem., 258, 5582 (1983) (Isolation & Seq.; Canine Bombesin-like Peptide)

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