Neuronostatin-13 (Human)

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SKU: 4452-v Category:

Neuronostatin-13 (Human)
(Chimpanzee, Porcine, Canine, Ovine, Biovine, chicken)

4452-v 0.5 mg | 95.00 EUR

Leu-Arg-Gln-Phe-Leu-Gln-Lys-Ser-Leu-Ala-Ala-Ala-Ala-NH2

(M.W. 1415.7) C64H110N20O16

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Neuronostatin-13 a Brain/Gut Hormone in Pro-Somatostatin with Neuronal/Neuroendocrine/Cardiovascular Activity

In the post-genome era, a novel peptide called Neuronostatin-13 has been predicted in pro-somatostatin gene sequence based on bioinformatics method. Neuronostatin-13 was purified from porcine tissue by immuno-affinity procedure and then confirmed to be an endogenous peptide. Actually Neuronostatin-13 (Human) is a 13 amino acid residue peptide with carboxyl-terminal amidation, the primary structure is conserved in human chimpanzee and some other mammals.

The biological functions of Neuronostatin-13 reported so far include:

  1. Intracerebroventricular administration of Neuronostatin-13 in rats increased blood pressure but suppressed food intake and water drinking (0.3 nmol per rat).
  2. in both brain and gastric cells, Neuronostatin-13 stimulatesc-Fos expression and cell profileration/migration.
  3. this peptide depresses cardiac contractile function.

Thus, neuronostatin-13 might be a new member of brain/gut hormones. In addition, the function of neuronostatin-13 is not mediated by somatostatin receptors. Neuronostatin-13 with "diverse neuronal, neuroendocrine and cardiovascular actions" could be of interest in the reseach field of hormon regulation of the body.

References:

  1. W.K. Samson, J.V. Zhang, O. Avsian-Kretchmer, K. Cui, G.L.C. Yosten, C. Klein, R.M. Lyu, Y.X. Wang, X.Q. Chen, J. Yang, C.J. Price, T.D. Hoyda, A.V.Ferguson, X.-bin Yuan, J.K.Chang and A.J.W. Hsueh, J. Biol. Chem., 283, 31949 (2008) (Original)
  2. Y. Hua, H. Ma, W.K.Samson and J. Ren, Am. J. Physiol. Regul. Integr. Comp. Physiol., 297, 682 (2009) (Pharmacol)

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