Orexin B (Human)

85,00 € excl. 19% VAT

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SKU: 4348-s Category:

Orexin B (Human)

4348-s 0.1 mg | 85.00 EUR

Arg – Ser – Gly – Pro – Pro – Gly – Leu – Gln – Gly – Arg – Leu – Gln – Arg – Leu – Leu – Gln – Ala – Ser – Gly – Asn – His – Ala – Ala – Gly – Ile – Leu – Thr – Met – NH2

(M.W. 2899.3) C123H212N44O35S [205640-91-1]

Synthetic Product

The purity is guaranteed to be higher than 99% by HPLC

Appetite-Boosting Peptide

Orexin-B is a linear 28-residue peptide. The mutual sequence similarity to Orexin-A is high, especially in their C-terminal regions. Human, rat and mouse peptide sequences have been determined and the primary structure of orexin-A is completely conserved among these species including bovine. Orexin B stimulates food intake in a dose-dependent manner (3/30 nmol) for a few hours with slight duration difference. In addition, hypothalamic orexin mRNA is found to be up-regulated in fasting. Orexin-B and A are coded tandemly in the same mRNA flanked by the double basic amino acid residues.

The same mRNA was isolated by another group from rat hypothalamic mRNA clone; the putative reading frames corresponding to orexin-A and B are named hypocretin based on the sequence similarity to secretin. [Proc. Natl. Acad. Sci., 95, 322 (1998)]

Shipping | Storage | Stability
Our product Orexin B will be shipped at room temperature. Information about product specific storage conditions can be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

  1. T. Sakurai, A. Amemiya, M. Ishii, I. Matsuzaki, R.M. Chemelli, H. Tanaka, S.C. Williams, J.A. Richardson, G.P. Kozlowski, S. Wilson, J.R.S. Arch, R.E. Buckingham, A.C. Haynes, S.A. Carr, R.S. Annan, D.E. McNulty, W.-S. Liu, J.A. Terrett, N.A. Elshourbagy, D.J. Bergsma and M. Yanagisawa, Cell, 92, 573 (1998) (Original)
  2. L. de Lecea, T.S. Kilduff, C. Peyron, X.-B. Gao, P.E. Foye, P.E. Danielson, C. Fukuhara, E.L.F. Battenberg, V.T. Gautvik, F.S. Bartlett II, W.N. Frankel, A.N. van den Pol, F.E. Bloom, K.M. Gautvik and J.G. Sutcliffe, Proc. Natl. Acad. Sci. USA, 95, 322 (1998) (cDNA; SAme Sequence [Hypocretin])

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