PAMP-12 (Human)
Proadrenomedullin N-terminal 20 Peptide (Human, 9 – 20)

4339-v 0.5 mg | 78.00 EUR

Synthetic Product

Phe – Arg – Lys – Lys – Trp – Asn – Lys – Trp – Ala – Leu – Ser – Arg – NH₂

The purity is guaranteed to be higher than 99% by HPLC

Hypotensive Peptide / Major endogenous form of PAMP

PAMP-12 [PAMP (9-20)] is described as an endogenous and very potent dodeca peptide. It is identified as the C-terminus of Proadrenomedullin N-terminal 20 peptide or its gene related peptide Adrenomedullin . These peptides play an important role in hypertension diseases, often in combination with a normal renal function. It was reported that in cases of organ damage, accompanied by hypertension, the plasma concentration of PAMP-12 was significantly higher than in cases without organ damage. Captopril shows no effect on the levels of Adrenomedullin or PAMP-12 in plasma.

References:

1. K. Kuwasato, K. Kitamura, Y. Ishiyama, H. Washimine, J. Kato, K. Kangawa and T. Eto, FEBS Lett., 414, 105 (1997) (Original)