Phosphoramidon
4082-v 0.5 mg | 50.00 EUR
N- (α- Rhamnopyranosyloxyhydroxyphosphinyl)- L- Leucyl- L- Tryptophan
| (M.W. 543.51) | C23H34N3O10P | [36357-77-4] |
| 4082-25 | 25 mg | 180.00 EUR |
| 4082-100 | 100 mg | 450.00 EUR |
N- (α-Rhamnopyranosyloxyhydroxyphosphinyl)- L- Leucyl- L- Tryptophan · 2Na · 2H2O
| (M.W. 541.49 · 45.98 · 36.03) | C23H34N3O10P · 2Na · 2H2O | [119942-99-3] |
Microbial Product (Sodium Salt)
Phosphoramidon is a very potent inhibitor for Thermolysin, Neutral Endopeptidase-24.11 (ANP Degradation Enzyme) and Endothelin Converting Enzyme (ECE)
Phosphoramidon is a less toxic enzyme inhibitor isolated from culture media of several actinomycetes and inhibits thermolysin, bacterial metallo-endopeptidases and mammalian enkephalinase. The sodium salt is soluble in water, methanol and DMSO.
References:
- H. Suda, T. Aoyagi, T. Takeuchi and H. Umezawa, J. Antibiotics, 26, 621 (1973) (Original)
- S.L. Stephenson and A.J. Kenny, Biochem. J, 243, 183 (1987) (Pharmacol.)
- Y. Matsumura, K. Hisaki, M. Takaoka and S. Morimoto, Eur. J. Pharmacol., 185, 103 (1990) (Pharmacol.)
- B.P. Roques and A. Beaumont, Trends Pharmacol. Sci., 11, 245 (1990) (Review)
Phosphoramidon is distributed through Peptide Institute, Inc. under the technical and scientific advices of Microbial Chemistry research Foundation
