Phosphoramidon

40,00 € excl. 19% VAT

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Phosphoramidon

4082-v 0.5 mg | 40.00 EUR

N- (α- Rhamnopyranosyloxyhydroxyphosphinyl)- L- Leucyl- L- Tryptophan

(M.W. 543.51) C23H34N3O10P [36357-77-4]

4082-25 25 mg 110.00 EUR
4082-100 100 mg 370.00 EUR

N- (α-Rhamnopyranosyloxyhydroxyphosphinyl)- L- Leucyl- L- Tryptophan · 2Na · 2H2O

(M.W. 541.49 · 45.98 · 36.03) C23H34N3O10P · 2Na · 2H2O [119942-99-3]

Microbial Product (Sodium Salt)

Phosphoramidon is a very potent inhibitor for Thermolysin, Neutral Endopeptidase-24.11 (ANP Degradation Enzyme) and Endothelin Converting Enzyme (ECE)

Phosphoramidon is a less toxic enzyme inhibitor isolated from culture media of several actinomycetes and inhibits thermolysin, bacterial metallo-endopeptidases and mammalian enkephalinase. The sodium salt is soluble in water, methanol and DMSO.

References:

  1. H. Suda, T. Aoyagi, T. Takeuchi and H. Umezawa, J. Antibiotics, 26, 621 (1973) (Original)
  2. S.L. Stephenson and A.J. Kenny, Biochem. J, 243, 183 (1987) (Pharmacol.)
  3. Y. Matsumura, K. Hisaki, M. Takaoka and S. Morimoto, Eur. J. Pharmacol., 185, 103 (1990) (Pharmacol.)
  4. B.P. Roques and A. Beaumont, Trends Pharmacol. Sci., 11, 245 (1990) (Review)

Phosphoramidon is distributed through Peptide Institute, Inc. under the technical and scientific advices of Microbial Chemistry research Foundation

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