(Tarantula, Thrixopelma pruriens)
4450-s 0.1 mg | 150.00 EUR
Tyr- Cys- Gln- Lys- Trp- Met- Trp- Thr- Cys- Asp- Ser- Glu- Arg- Lys- Cys- Cys- Glu- Gly- Met- Val- Cys- Arg- Leu- Trp- Cys- Lys- Lys- Lys- Leu- Trp
Synthetic Product (disulfide bonds between Cys2– Cys16, Cys9– Cys21 and Cys15– Cys25 ) and not from animal origin
The purity is guaranteed to be higher than 99% by HPLC
Na+ Channel (Especially Nav1.7) / Ca2+ Channel Blocker (Gating Modifier)
ProTx-II was originally isolated from the venom of the tarantula Thrixopelma pruriens. Potent channel blocker with high selectivity for Nav1.7 channel.
ProTx-II is a potent inhibitor for tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels. The Nav1 type channels exists in different sub types and ProTx-II shows a special affinity to the Nav1.7 channel which is responsible for pain processing.
- R.E. Middleton, V.A. Warren, R.L. Kraus, J.C. Hwang, C.J. Liu, G. Dai, R.M. Brochu, M.G. Kohler, Y.-D. Gao, V.M. Garsky, M.J. Bogusky, J.T. Mehl, C.J. Cohen and M.M. Smith, Biochemistry, 41, 14734 (2002) (Original)
- J.J. Smith, T.R. Cummins, S. Alphy and K.M. Blumenthal, J. Biol. Chem., 282, 12687 (2007) (Pharmacol.; Novel Toxin Binding Site Coupled to NaV Activation)
- W.A. Schmalhofer, J. Calhoun, R. Burrows, T. Bailey, M.G. Kohler, A.B. Weinglass, G.J. Kaczorowski, M.L. Garcia, M. Koltzenburg and B.T. Priest, Mol. Pharmacol., 74, 1476 (2008) (Pharmacol.; Inhibition of Nav1.7 Channel)
- B.T. Priest, K.M. Blumenthal, J.J. Smith, V.A. Warren, and M.M. Smith, Toxicon, 49, 194 (2007) (Review)
Links to publications that use our peptide Protoxin II (ProTX-II) | code 4450-s: