Stichodactyla Toxin
ShK (Sea Anemone, Stichodactyla helianthus)

4287-s 0.1 mg | 145.00 EUR

Arg – Ser – Cys – Ile – Asp – Thr – Ile – Pro – Lys – Ser – Arg – Cys – Thr – Ala – Phe – Gln – Cys – Lys – His – Ser – Met – Lys – Tyr – Arg – Leu – Ser – Phe – Cys – Arg – Lys – Thr – Cys – Gly – Thr – Cys

Synthetic Product (disulfide bonds between Cys³– Cys³⁵, Cys¹²– Cys²⁸ and Cys¹⁷– Cys³² )

The purity is guaranteed to be higher than 99% by HPLC

Voltage-Dependent K⁺ Channel (A Channel) Blocker

Stichodactyla Toxin (ShK) is a 35-residue polypeptide originally isolated from the sea anemone Stichodactyla helianthus venom. It is a selective ion channel blocker for different types of voltage-gated potassium channels. Stichodactyla Toxin (ShK) manufactured at Peptide Institute Inc. is from chemical origin and not made by recombinant methods, therefore crosscontamination with E. Coli protein residues must not to be apprehanded.

Shipping | Storage | Stability
Our product Stichodactyla Toxin will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. E. Karlsson, A.L. Harvey, A. Aneiros and O. Castaneda, Toxicon, 31, 504 (1993) (Original)
2. J. Pohl, F. Hubalek, M.E. Byrnes, K.R. Nielsen, A. Woods and M.W. Pennington, Lett. Pept. Sci., 1, 291 (1994) (S-S Bond)
3. Castañeda, V.Sotolongo, A.M. Amor, R. Stöcklin, A.J. Anderson, A.L. Harvey, Å. Engström, C. Wernstedt and E. Karlsson, Toxicon, 33, 603 (1995) (Pharmacon.)