Uroguanylin (Human)

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Uroguanylin (Human)

4295-s 0.1 mg 85.00 EUR
4295 5 x 0.1 mg 305.00 EUR

Asn – Asp – Asp – Cys – Glu – Leu – Cys – Val – Asn – Val – Ala – Cys – Thr – Gly – Cys – Leu

(M.W. 1667.9) C64H102N18O26S4 [154525-25-4]

Synthetic Product (disulfide bonds between Cys4-Cys12 and Cys7-Cys15)

The purity is guaranteed to be higher than 99% by HPLC

Intestinal peptide hormone | Regulator for electrolyte/fluid transport in the gastrointestinal epithelium

Human uroguanylin is a 16 mer intestinal peptide with 2 disulfide bonds and acts as a potent guanylate Cylase C agonist. Uroguanylin shows a very high structural similarity to the heat resistant E.Coli Enterotoxin (STa).

References:

  1. T. Kita, C.E. Smith, K.F. Fok, K.L. Duffin, W.M. Moore, P.J. Karabatsos, J.F. Kachur, F.K. Hamra, N.V. Pidhorodeckyj, L.R. Forte and M.G. Currie, Am. J. Physiol., 266, F342 (1994) (Original)
  2. M. Nakazato, H. Yamaguchi, H. Kinoshita, K. Kangawa, H. Matsuo, N. Chino and S. Matsukura, Biochem. Biophys. Res. Commun., 220, 586 (1996) (Biologically Active / Inactive isomer)
  3. H. Kinoshita, S. Fujimoto, M. Nakazato, N. Yokota, Y. Date, H. Yamaguchi, S. Hisanaga and T. Eto, Kidney Int., 52, 1028 (1997) (Urine and Plasma Level of Uroguanylin; Renal Disease)
  4. N. Chino, S. Kubo, T. Kitani, T. Yoshida, R. Tanabe, Y. Kobayashi, M. Nakazato, K. Kangawa and T. Kimura, FEBS Lett., 421, 27 (1998) (Biochemistry of Uroguanylin; Topological Isomers)

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