Z-Gly-Pro-Arg-AMC

45,00 € excl. 19% VAT

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Z-Gly-Pro-Arg-AMC

Z-GPR-AMC | Z-Gly-Pro-Arg-MCA

3208-v 5 mg | 45.00 EUR

Benzyloxycarbonyl- glycyl- L-prolyl- L-arginine- 4-methylcoumaryl-7-amide

(M.W. 619.67) C31H37N7O7 [201928-42-9]

Synthetic Product (Hydrochloride Form)
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Substrate for Cathepsin K

Our tripeptide Z-Gly-Pro-Arg-AMC manufactured at Peptide Institute, Inc. is used as highly activ fluorogenic substrate for the routinous determination of Cathepsin K activity.
Z-Gly-Pro-Arg-AMC is cleaved by granzyme A and thrombin as well.

References:

  1. K. Aibe, H. Yazawa, K. Abe, K. Teramura, M. Kumegawa, H. Kawashima and K. Honda, Biol. Pharm. Bull., 19, 1026 (1996)
  2. F. Bühling, A. Gerber, C. Häckel, S.Krüger, T. Köhnlein, D. Bröhme, D. Reinhold, S. Ansorge and T. Welte, Am. J. Respir. Cell. Mol. Biol., 20, 612 (1999)
  3. O. Krahenbuehl et al, J. Immunol., 141, 3471 (1988)

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