Z-Leu-Arg-AMC

Z-Leu-Arg-AMC

Z-LR-AMC | Z-Leu-Arg-MCA

3210-v 5 mg | 65.00 EUR

Benzyloxycarbonyl- L-leucyl- L-arginine 4-methylcoumaryl-7-amide

(M.W. 578,66) C30H38N6O6

Synthetic Product (Hydrochloride Form)
A trace of impurity might be detectable by TLC when 100 µg is applied to the plate. The amount of contamination detectable by HPLC is less than 2 %.

Substrate for Cathepsin K / S / V

The Benzyloxycarbonyl-protected Dipeptide Z-Leu-Arg-AMC was carfully manufactured at Peptide Institute and is a widly used fluorogenic substrate for Cathepsine K, S and V. (Z-Leu-Arg-MCA is used in Japan as synonym for Z-Leu-Arg-AMC)

References:

  1. D. Brömme, K. Okamoto, B.B. Wang and S. Biroc, J. Biol. Chem., 271, 2126 (1996)
  2. D. Brömme, Z. Li, M. Barnes and E. Mehler, Biochemistry, 38, 2377 (1999)