Z-Leu-Leu-Leu-H (aldehyde) [MG-132]
Z-Leu-Leu-Leu-aldehyde | Calpain Inhibitor IV
3175-v 5 mg | 44.00 EUR
Benzyloxycarbonyl- L-Leucyl- L-Leucine- L-Leucinal
Inhibitor for Proteasome and Cathepsin K
Z-Leu-Leu-Leu-aldehyde [MG-132] is very strong inhibitor of calpain
The selective proteasome inhibitor MG-132 (Calpain Inhibitor IV) is a tripeptide aldehyde with the sequence Z-Leu-Leu-Leu-H (aldehyde) and is depending to its hydrophob sequence poorly soluble in water or in aqueous buffers. MG-132 is soluble in several organic solvents like DMSO (25 mg/ml), Ethanol (25 mg/ml), Methanol or DMF. To prepare aqueous stock solutions, MG-132 should be dissolved first in organic solvents and then carefully diluted into aqueous buffers. Aqueous stock solutions of Z-Leu-Leu-Leu-H [MG132] should not be stored for longer, because of the terminal aldehyde, which is subject to oxidation. MG-132 (Z-Leu-Leu-Leu-aldehyde) will be shipped at room temperature and should be stored after receipt in a freezer.
It is reported that the combination of MG-132 with the proteasomal inhibitor Lactacystin may induce synergistic apoptosis in prostate cancer cells.
- Y. Saito, S. Tsubuki, and S. Kawashima, Neurosci. Lett., 120, 1 (1990) Description MG-132
- T.J. Jensen, M.A. Loo, S. Pind, D.B. Williams, A.L. Goldberg, and J.R. Riordan, Cell, 83, 129 (1995)
- B.J. Votta, M.A. Levy, A. Badger, J. Bradbeer, R.A. Dodds, I.E. James, S. Thompson, M.J. Bossard,T. Carr, J.R. Conner, T.A. Tomaszek, L. Szewczuk, F.H. Drake, D.F. Vaber and M. Gowen, J. Bone Miner. Res., 12, 1396 (1997)
Z-Leu-Leu-Leu-H [MG-132] is distributed through Peptide Institute, Inc. under the license of Dr. H. Ito.