Z-Leu-Leu-Nle-aldehyde

245,00 € excl. 19% VAT

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SKU: 649-27 Category:

Z-Leu-Leu-Nle-aldehyde

gamma-Secretase inhibitor

649-27 5 mg | 245.00 EUR

Benzyloxycarbonyl-L-Leucyl-L-Leucine-L-Norleucinal

(M.W. 475.3) C26H41N3O5

Synthetic Product
Manufacturer: California Peptide Research Inc.

The Z-protected tripeptide aldehyde Z-Leu-Leu-Nle-CHO is used as an inhibitor for gamma-Secretase. Since APP ( Amyloid Precursor Protein) is cleaved by this proteolytic enzyme, it is suspected that the blocking of γ-secretase may be of interest in Alzheimer’s disease research.

References:

  1. T. Hartmann et al., Nat. Med., 3, 1016 (1997)

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