ω-Conotoxin MVIIC
Omega-Conotoxin MVIIC
(Marine Snail, Conus magus)

4283-s 0.1 mg | 150.00 EUR
4283-v 0.5 mg | 310.00 EUR

Synthetic Product (disulfide bonds between Cys¹-Cys¹⁶, Cys⁸-Cys²⁰ and Cys¹⁵-Cys²⁶)

Cys - Lys - Gly - Lys - Gly - Ala - Pro - Cys - Arg - Lys - Thr - Met - Tyr - Asp - Cys - Cys - Ser - Gly - Ser - Cys - Gly - Arg - Arg - Gly - Lys - Cys - NH₂

(M.W. 2749.3)

C106H178N40O32S7

[147794-23-8]

The purity is guaranteed to be higher than 99% by HPLC

P / Q-type Ca²⁺ Channel Blocker

The synthetic peptide toxin omega-Conotoxin MVIIC is a P/Q-type calcium channels with high affinity. It blocks as well N-type calcium channels with low affinity. omega-Conotoxin MVIIC labeled with [125I] is used as diagnostical tool in the research of Lambert-Eaton myasthenic syndrome.

References:

1. R.R. Hillyard, V.D. Monje, I.M. Mintz, B.P. Bean, L. Nadasdi, J. Ramachandran, G. Miljanich, A. Azimi-Zoonooz, J.K.McIntosh, L.J. Cruz, J.S. Imperial and B.M. Olivera, Neuron, 9, 69 (1992) (Original; cDNA and Pharmacol.)
2. M.E. Adams, R.A. Myers, J.S. Imperial, and B.M. Olivera, Biochemistry, 32, 12566 (1993) (Pharmacol.)
3. W.A. Sather, T. Tanabe, J.F. Zhang, Y. Mori, M.E. Adams and R.W. Tsien, Neuron, 11, 291 (1993) (Pharmacol.)
4. D.B. Wheeler, A. Randall and R.W. Tsien, Science, 264, 107 (1994) (Pharmacol.)