Alpha-Defensin-6 (Human)
α-Defensin-6 | HD-6 (Human Defensin-6)

4458-s 0.1 mg | 220.00 EUR

Synthetic Product (disulfide bonds between Cys⁴-Cys³¹, Cys⁶-Cys²⁰ and Cys¹⁰-Cys³⁰)

Ala - Phe - Thr - Cys - His - Cys - Arg - Arg - Ser - Cys - Tyr - Ser - Thr - Glu - Tyr - Ser - Tyr - Gly - Thr - Cys - Thr - Val - Met - Gly - Ile - Asn - His - Arg - Phe - Cys - Cys - Leu

(M.W. 3708.2)

C156H228N46O46S7

The purity of alpha-Defensin-6 is guaranteed to be higher than 99% by HPLC

HD-6 (Human) | Alpha-Defensin-6 (Human) was originally isolated from neobladder urine as a 32-residue peptide. Heliobacter pylori infection increases HD-6 expression. Peptide inhibits herpes simplex virus infection and has influenza A virus neutralizing ability. In Crohn´s disease patients show reduced alpha-Defensin-6 level.

References:

1. D.E. Jones and C.L. Bevins, FEBS Lett., 315, 187 (1993)
2. E.M. Porter, M.A. Poles, J.S. Lee, J. Naitoh, C.L. Bevins and T. Ganz, FEBS Lett. 434, 272 (1998) (Endogenous Form)
3. E. Hazrati, B. Galen, W. Lu, W. Wang, Y. Ouyang, M.J. Keller, R.I. Lehrer and B.C. Herold, J. Immunol., 177, 8658 (2006) (Pharmacol. inhibition herpes simplex virus infection)