Beta-Defensin-2 (Human)
hBD-2 | Human β-Defensin-2

4338-s 0.1 mg | 220.00 EUR

Synthetic Product (disulfide bonds between Cys⁸-Cys³⁷, Cys¹⁵-Cys³⁰ and Cys²⁰-Cys³⁸)

Gly - Ile - Gly - Asp - Pro - Val - Thr - Cys - Leu - Lys - Ser - Gly - Ala - Ile - Cys - His - Pro - Val - Phe - Cys - Pro - Arg - Arg - Tyr - Lys - Gln - Ile - Gly - Thr - Cys - Gly - Leu - Pro - Gly - Thr - Lys - Cys - Cys - Lys - Lys - Pro

(M.W. 4328.2)

C188H305N55O50S6

The purity of Human Beta-Defensin-2 is guaranteed to be higher than 99% by HPLC

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The antimicrobial peptide Human Beta-Defensin-2 was originally isolated from skin cells from Psoriasis-patients. The expression of hBD-2 by skin cells is a direct response to a local infection by Pseudomonas aeruginosa or other bacteria. Peptide LL-37 and hBD-2 might be able to protect the skin of patients with psoriasis and both peptides may be involved in the pathogenesis of psoriasis.
Additionally beta-Defensin-2 is suspected to play a distinct role in Crohn's disease.
Beta-Defensin-2 (human) offered from PeptaNova is a chemical synthesized peptide of highest purity.

References:

1. T. Harder, J. Bartels, E. Christophers and J.M. Schröder, Nature, 387, 861 (1997) (Original; Human Beta-Defensin-2)
2. T. Hiratsuka, M. Nakazato, Y. Date, J. Ashitani, T. Minimatsu, N. Chino and S. Matsukura, Biochem. Biophys. Res. Commun., 249, 943 (1998) (Pharmacology of hBD-2)
3. D.M. Hoover, K.R. Rajashankar, R. Blumenthal, A. Puri, J.J. Oppenheim, O. Chertov and J. Lubkowski, J. Biol. Chem., 275, 32911 (2000) (S-S Bond)
4. T. Hiratsuka, H. Mukae, H. Iiboshi, J. Ashitani, K. Nabeshima, T. Minimatsu, N. Chino, T. Ihi, S. Kohno and M. Nakazato, Thoray, 58, 425 (2003) (Pharmacol; Activity of beta-Defensin-2 against Pseudimonas aeruginosa)