ω-Agatoxin IVA
ω-Aga-IVA | omega-Aga-IVA (Funnel Web Spider, Agelenopsis aperta)

4256-s 0.1 mg | 245.00 EUR

Synthetic Product (Disulfide bonds between Cys⁴-Cys²⁰, Cys¹²-Cys²⁵, Cys¹⁹-Cys³⁶ and Cys²⁷-Cys³⁴)

Lys - Lys - Lys - Cys - Ile - Ala - Lys - Asp - Tyr - Gly - Arg - Cys - Lys - Trp - Gly - Gly - Thr - Pro - Cys - Cys - Arg - Gly - Arg - Gly - Cys - Ile - Cys - Ser - Ile - Met - Gly - Thr - Asn - Cys - Glu - Cys - Lys - Pro - Arg - Leu - Ile - Met - Glu - Gly - Leu - Gly - Leu - Ala

(M.W. 5202.2)

C217H360N68O60S10

The purity is guaranteed to be higher than 99% by HPLC

The neuropeptide toxin Omega-Agatoxin IVA is a strong P-type Ca²⁺ Channel selective blocker. Omega-Aga-IVA is altering the voltage-dependent gating, so that very large depolarizations are needed for channel opening.

References:

1. I.M. Mintz, V.J. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean, and M.E. Adams, Nature, 355, 827 (1992)(Original)
2. T.J. Turner, M.E. Adams, and K. Dunlap, Science, 258, 310 (1992) (Pharmacol)
3. H. Nishio, K.Y. Kumagaye, S. Kubo, Y.-N. Chen, A. Momiyama, T. Takahashi, T. Kimura, and S. Sakakibara, Biochem. Biophys. Res. Commun, 196, 1447 (1993) (Chemical synthesis of omega-Agatoxin IVA and Biological activity)

Omega-Agatoxin IVA is distributed in the USA through Peptide Institute, Inc. Omega-Agatoxin IVA is not available in the USA via PeptaNova.