Pepstatin A

PURITY: higher than 90% (HPLC) | higher solubility

4397-v 0.5 mg | 36.00 EUR


Isovaleryl- L- Val- L- Val- AHMHA- L- Ala- AHMHA
(AHMHA: (3S,4S)- 4- Amino- 3- Hydroxy- 6- Methyl- Heptanoic Acid)

(M.W. 685.89)

C34H63N5O9

[26305-03-3]

4397-25	25 mg	56.00 EUR
4397-100	100 mg	140.00 EUR
4397-1g	1 g	1.125.00 EUR

Isovaleryl- L- Val- L- Val- AHMHA- L- Ala- AHMHA
(AHMHA: (3S,4S)- 4- Amino- 3- Hydroxy- 6- Methyl- Heptanoic Acid)

(M.W. 685.89)

C34H63N5O9

[26305-03-3]

Microbial Product

Inhibitor for Pepsin, Cathepsin D/E and Renin

Pepstatin A is a specific and less toxic inhibitor for acidic proteases like Pepsin, HIV- und MMTV-Protease, Cathepsin D and Renin. Extracellular protease activities in cell cultures can be suppressed by using Pepstatin A in combination with Chymostatin. Our inhibitor Pepstatin A is of microbial origin and was isolated and purified from culture medium. Pepstatin A is always less soluble in usualy used solvents. After an optimised down stream processing we received Pepstatin A in excellent purity compared with higher solubility in commonly used buffers or solvents. Addition of acidic acid will increase solubility. The solvent can be heated slightly during dissolving process.

Shipping | Storage | Stability
Our product Pepstatin A will be shipped at room temperature. Information about product specific storage conditions will be found on the vial. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. H. Umezawa, T. Aoyagi, H. Morishima, M. Matsuzaki, M. Hamada and T. Takeuchi, Antibiotics, 23, 259 (1970) (Original)
2. T. Aoyagi, H. Morishima, R. Nishizawa, S. Kunimoto, T. Takeuchi, H. Umezawa and H. Ikezawa, Antibiotics, 25, 289 (1972) (Biological Activity)

Links to publications that use our inhibitor Pepstatin A | code 4397:

1. Signaling Pathways of the TREM-1- and TLR4-Mediated Neutrophil Oxidative Burst

In 2003, we started to distribute Pepstatin A of the purity "higher than 90%" when analyzed by RP-HPLC (Code 4397). This new item was welcomed by the majority of customerers. However, this accompanied some complaints because of its low solubility. At the beginning, we thought this low solubility is the destiny of the higher purity Pepstatin A. In striving to offer our customers satisfactory service, we continued to improve the solubility of this item. Recently, we have succeded to obtain both high purity Pepstatin A and higher solubility. This new improved Pepstatin A is now available from us with easier handling.