Ac-DEVD-CHO | Ac-Asp-Glu-Val-Asp-H (aldehyde)

3172-v 5 mg | 148.00 EUR

Acetyl- L-aspartyl- L-glutaminyl- L-threonyl- L-aspart-1-al

Synthetic Product

Reversible inhibitor for Caspase-3/7/8

The frequently used Caspase 3/7 inhibitors from type DEVD are similar to a short partial sequence of the DNA repair enzyme Poly (ADP- ribose) polymerase. The reversible inhibitor Ac-DEVD-CHO is corresponding to the related and often used AMC substrate Ac-DEVD-AMC code: 3171-v. Both peptides the inhibitor and the substrate are available for prompt delivery ex stock Sandhausen.

References:

1. D.W. Nicholson, A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnik, N.A. Munday, S.M. Raju, M.E. Smulson, T.-T. Yamin, V.L. Yu and D.K. Miller, Nature, 376, 37 (1995)
2. M. Enari, R.V. Talanian, W.W. Wong and S. Nagata, Nature, 380, 723 (1996)
3. N.A. Thornberry, T.A. Rano, E.P. Peterson, D.M. Rasper, T. Timkey, M. Garcia-Calvo, V.M. Houtzager, P.A. Nordstrom, S. Roy, J.P. Vaillancourt, K.T. Chapman and D.W. Nicholson, J. Biol. Chem., 272, 17907 (1997)

Links to publications that use our caspase inhibitor Ac-DEVD-CHO | code 3172-v:

1. RIP1-Dependent Programmed Necrosis is Negatively Regulated by Caspases During Hepatic Ischemia-Reperfusion
   
2. Inflammatory Response of Lung Macrophages and Epithelial Cells after Exposure to Redox Active Nanoparticles: Effect of Solubility and Antioxidant Treatment