Alpha-Defensin-5 (Human)
α-Defensin-5 | HD-5

4415-s 0.1 mg | 235.00 EUR

Synthetic Product (disulfide bonds between Cys³-Cys³¹, Cys⁵-Cys²⁰ and Cys¹⁰-Cys³⁰)

Ala – Thr – Cys – Tyr – Cys – Arg – Thr – Gly – Arg – Cys – Ala – Thr – Arg – Glu – Ser – Leu – Ser – Gly – Val – Cys – Glu – Ile – Ser – Gly – Arg – Leu – Tyr – Arg – Leu – Cys – Cys – Arg

The purity of Alpha-Defensin-5 is guaranteed to be higher than 99% by HPLC

Antimicrobial Peptide in Paneth Cells

Alpha-Defensin-5 (HD-5) is expressed in Paneth cells in intestinal epithelium, thus, falls into a distinct subclass of human alpha-Defensin. The in vivo role of HD-5 was studied in transgenic mouse models injected by an HD-5 minigene, confirming that HD-5 expression was specific to Paneth cells and resulted in resistance to bacterial challenge. In patients with HIV related cryptosporidiosis, HD-5 immunoreactivity was reduced. In inflammatory bowel disease, HD-5 was expressed in metaplastic Paneth cells in the colon. These evidences together point to HD-5 as an essential factor in the defense against intestinal inflammation.
HNP-1 and HNP-3, as well as HD-5, should be valuable tools to clarify the function and mechanism of innate immunity in human beings.
New flow cytometric studies: α-defensin-5 and α-defensin-1 where identified as inhibitors of pertussis toxin.

References:

1. T. Ganz, M.E. Selstedt, D. Szklarek, S.S.L. Harwig, K. Daher, D.F. Bainton and R.I. Lehrer, J. Clin. Invest., 76, 1427 (1985) (Original; Isolation of HNP 1-3)
2. M.E. Selstedt, S.S.L. Harwig, T. Ganz, J.W. Schilling and R.I. Lehrer, J. Clin. Invest., 76, 1436 (1985) (Original; Structure of HNP 1-3)
3. C.E. Mackewicz, J. Yuan, P. Tran, L. Diaz, E. Mack, M.E. Selsted and J.A. Levi, AIDS, 17, F23 (2003)
4. F.T. Lundy, D.F. Orr, J.R. Gallagher, P. Maxwell, C. Shaw, S.S. Napier, C.G. Cowan, P.J. Lamey and J.J. Marley, Oral. Oncol., 40, 139 (2004) (Pharmacol.; Role in Tumor Invasion)
5. X.M. Fang, Q. Shu, Q.X. Chen, M. Book, H.G. Sahl, A. Hoeft and F. Stuber, Eur. J. Clin. Invest., 33, 82 (2003) (Histochem.; Regulation of Expression)
6. R.N. Cunliffe, Mol. Immunol., 40, 463 (2003) (Histochem.; α-Defensin in Gastointestinal Tract)
7. D.E. Jones and C.L. Bevins, J. Biol. Chem., 267, 23216 (1992) (Original; human alpha-Defensin-5)
8. E.M. Porter, M.A. Poles, J.S. Lee, J. Naitoh, C.L. Bevins and T. Ganz, FEBS Lett., 434, 272 (1998) (Pharmacol. of Defensin; endogenous Form)
9. N.H. Salzman, D. Gosh, K.M. Huttner, Y. Paterson and C.L. Bevins, Nature, 422, 522 (2003) (Pharmacol.)
10. P. Kelly, R. Feakins, P. Domizio, J. Murphy, C. Bevins, J. Wilson, G. Mcphail, R. Poulsom and W. Dhaliwal, Clin. Exp. Immunol., 135, 303 (2004) (Histochem.; Location of Defensin in AIDS Patients)

Links to publications that use our antimicrobial peptide Alpha-Defensin-5 (HD-5) | code 4415-s:

1. Altered α-defensin 5 expression in cervical squamocolumnar junction: implication in the formation of a viral/tumour-permissive microenvironment (2014)
   
2. Inhibition of Pertussis Toxin by Human α-Defensins-1 and -5: Differential Mechanisms of Action
   

For Laboratory use only!