Elafin (Human)
Antimicrobial Peptide

4243-v 20 µg | 195.00 EUR

Ala – Gln – Glu – Pro – Val – Lys – Gly – Pro – Val – Ser – Thr – Lys – Pro – Gly – Ser – Cys – Pro – Ile – Ile – Leu – Ile – Arg – Cys – Ala – Met – Leu – Asn – Pro – Pro – Asn – Arg – Cys – Leu – Lys – Asp – Thr – Asp – Cys – Pro – Gly – Ile – Lys – Lys – Cys – Cys – Glu – Gly – Ser – Cys – Gly – Met – Ala – Cys – Phe – Val – Pro – Gln

Synthetic Product (disulfide bonds between Cys¹⁶-Cys⁴⁵, Cys²³-Cys⁴⁹, Cys³²-Cys⁴⁴and Cys³⁸-Cys⁵³)

The purity is guaranteed to be higher than 99% by HPLC

Elafin | Elastase-Specific Inhibitor from Human Skin

The human derived polypeptide Elafin is expressed in human skin, lungs, and mammary glands. It was first isolated from human epithelia. Elafin is a reversible, strong binding inhibitor of human leukocyte proteinase and elastase. Elafin represents a new type of elastase inhibitor with anti-microbial activity against Gram- positive and Gram-negative bacteria. Often used synonyms for Elafin: ESI (Elastase-specific Inhibitor), SKALP ( Skin-derived Antileukoproteinase ) and Protease Inhibitor WAP3. Elafin offered from PeptaNova is a chemically manufactured peptide and not recombinat from yeast or bacterial cell culture, therefore cross contamination must not be feared.

Elafin specific Antiserum is available from PeptaNova as well

Shipping | Storage | Stability
Elafin will be shipped at room temperature and long term storage at -20°C is recommended. Stock solutions should be stored at -20°C. Please avoid repeated freezing and thawing by preparing aliquots.

References:

1. O. Widenow, J.M.Schröder, H. Gregory, J.A. Young, E. Christophers, J. Biol. Chem., 265, 14791 (1990) (Original)
2. O. Widenow, J.M.Schröder, H. Gregory, J.A. Young, E. Christophers, J. Biol. Chem., 266, 3356 (1991) (Correction of Elafin Sequence)
3. M. Tsunemi, H. Kato, Y. Nishiuchi, S. Kumagaye and S. Sakakibara, Biochem. Biophys. Res. Commun, 185, 967 (1992) (Chem. Synthesis and Biochem. of Elafin)
4. M. Tsunemi, Y. Matsura, S. Sakakibara and Y. Katsube, Biochemistry, 35, 11570 (1996) (Biochem; Crystal Structure of Elafin-Pancreatic Elastase Complex)