Guangxitoxin-1E
GxTX-1E
(Spider, Tarantula, Plesiophrictus guangxiensis sp. nov)

4433-s 0.1 mg | 170.00 EUR

Glu – Gly – Glu – Cys – Gly – Gly – Phe – Trp – Trp – Lys – Cys – Gly – Ser – Gly – Lys – Pro – Ala – Cys – Cys – Pro – Lys – Tyr – Val – Cys – Ser – Pro – Lys – Trp – Gly – Leu – Cys – Asn – Phe – Pro – Met – Pro

Synthetic Product (disulfide bonds underterminded)

The purity of our product Guangxitoxin-1E is guaranteed to be higher than 99% by HPLC

Kv2.1/Kv2.2 Channel Blocker / Enhancer of Glucose-Dependent Insulin Secretion

Guangxitoxin-1E (GxTX-1E) is a strong inhibitor of the Kv current of β-cells. GxTX-1E enhances the glucose-dependent intracellular calcium elevations and increases the glucose-dependent insulin secretion. It is suspected that Guangxitoxin-1E blocks of Kv2.1 channel and may be a useful tool for the investigation of type 2 diabetes.

References:

1. J. Herrington, Y.-P. Zhou, R.M. Bugianesi, P.M. Dulski, Y. Feng, V.A. Warren, M.M. Smith, M.G. Kohler, V.M. Garsky, M. Sanchez, M. Wagner, K. Raphaelli, P. Banerjee, C. Ahaghotu, D. Wunderler, B.T. Priest, J.T. Mehl, M.L. Garcia, O.B. McManus, G.J. Kaczorowski and R.S. Slaughter, Diabetes., 55, 1034 (2006) (Original, GxTX-1E)
2. F. Bode, F. Sachs and M.R. Franz, Nature, 409, 35 (2001) (Pharmacology of Guangxitoxin-1E.)
3. P.E. MacDonald, S. Sewing, J. Wang, J.W. Joseph, P.E. MacDonald, S. Sewing, J. Wang, J.W. Joseph, S.R. Smukler, G. Sakellaropoulos, J.Wang, M.C. Saleh, C.B. Chan,R.G. Tsushima, A.M.F. Salapatek and M.B. Wheeler, J. Biol. Chem., 277, 44938 (2002) (Pharmacology of GxTX-1E; Role of Kv2.1 in Glucose-Dependent Insulin Secretion)
4. N.A. Tamarina, A. Kuznetsov, L.E. Fridlyand and L.H. Philipson, Am. J. Physiol. Endocrinol. Metab., 289, E578 (Pharmacol.; Role of Kv2.1 in Glucose-Dependent Ca2+ response)